We examined the expression of tumor suppressor gene product, p53 protein, immunohistochemically by using p53 monoclonal antibody and HPV type 16/18 infection by in situ hybridization of fluorescein-labelled probe in tissue obtained from 67 cases
of
the
uterine cervical cancer.
In this study, we analyzed that each data affect the prognosis of uterine cervical cancer, and examined the hypothesis of inverse correlation between the presence of HPV infection and the mutant p53 protein.
The overall expression the p53 protein was 23.9%. The expression rate was increased with advancing clinical stage, and the large cell keratinizing type has higher expression rate than nonkeratinizing type (42.1% vs 18.4%, p=0.01).
The infection rate of HPV type 16/18 was 70.1% and increased with advancing clinical stage, but other prognostic factors of cervical cancer were not correlated with p53 protein expression and HPV type 16/18 infection.
Compared expression rate of p53 with HPV type 16/18 infection, there was significant correlation between HPV type 16/18 positive tumor and negative expression of p53(p=0.043).
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